艾司西酞普兰与舍曲林治疗老年脑卒中后抑郁对照研究

艾司西酞普兰与舍曲林治疗老年脑卒中后抑郁对照研究冯连启

【期刊名称】《临床心身疾病杂志》

【年(卷),期】2015(000)003

【摘要】Objective To explore the efficacy and safety of escitalopram and sertraline in the treatment of senile post‐stroke depression (PSD) .Methods Eighty senile PSD patients were randomly divided into two groups ,both received neuro‐medical routine treatment and convalescent care ,on this basis research group took orally escitalopram and control group did sertraline for 8 week .Efficacies were assessed with the Hamilton Depression Scale (HAMD) before and after treatment and adverse reactions with the Treat‐ment Emergent Symptom Scale (TESS) .Results At the end of the 1st week the HAMD total score low‐ered more significantly in research than in control group (P<0 .01) ,at the end of the 8th w eek obvious ef‐fective and effective rate were respectively 80 .0% and 92 .5% in research and 70 .0% and 90 .0% in control group ,which showed no significant differences (P>0 .05) .Adverse reactions of both groups were mild , but dry mouth and diarrhea incidence were significantly lower in research than in control group ( P<0 .01) .Conclusion Escitalopram has an evident effect equivalent to sertraline in the treatment of PSD , but the former takes effect more rapidly ,has higher safety ,and is more suitable for senile