干扰素治疗儿童病毒性心肌炎疗效的Meta分析

干扰素治疗儿童病毒性心肌炎疗效的Meta分析

高淑贤;付立强;赵文萍;王艳飞;贾辛未;李雪松

【期刊名称】《中国小儿急救医学》

【年(卷),期】2016(023)010

【摘要】Objective To review the curative effect of interferon on children with viral myocarditis. Methods The databases of PubMed,MEDLINE,Cochrane Controlled Trials Register,CNKI(1979-2015), Wanfang Database(1998-2015)and VIP Database(1989-2015)were retrieved for collecting the randomized controlled trials( RCTs) on the comparison of treating children viral myocarditis with routine Western medical therapy combining interferon( experimental group) and routine Western medical therapy( control group) . The eligible RCTs were given Meta-analysis. Results There were totally 9 eligible RCTs and the quality of all RCTs reached grade C. The results of Meta-analysis showed that the curative effect was better in experimental group than that in control group and the total effective rate was Z=5. 96 ( P <0. 001 ) , OR 4. 07 ( 95%CI 2. 56-6. 45). When the treatment ended,the changes of myocardial enzymes and arrhythmia had statistical difference[respectively:Z=5. 59(P<0. 001),OR 4. 66(95%CI 2. 72-8.

00)and Z=5. 00(P<0. 001),OR 4. 62(95%CI 2. 54-8. 42)]. The analysis results of funnel plots showed that there was barely bias in the Meta-analysis on curative effect. Conclusion Routine Western medical therapy