右美托咪定对老年患者围术期心肌功能的影响观察

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右美托咪定对老年患者围术期心肌功能的影响观察

作者：黄旭

来源：《中国医药科学》2015年第02期

[摘要] 目的观察右美托咪定用于老年患者对围手术期心肌功能的保护作用。方法选择58例择期行全髋置换术的老年患者随机分为两组，观察组29例，在麻醉诱导前给予右美托咪定静注，对照组29例，不额外给予右美托咪定或其他影响心肌功能的药物，对两组的心肌缺血性改变发生率及血流变学以及血清cTnⅠ及GP-BB的变化情况进行观察及比较。结果观察组心电图心肌缺血性改变发生率6.90%明显低于对照组31.03%;手术结束时两组的血清cTnⅠ及GP-BB均较麻醉前升高（P

[关键词] 右美托咪定;心肌功能;老年患者

[中图分类号] R614 [文献标识码] B [文章编号] 2095-0616（2015）02-46-03

The observation of the perioperative myocardial function of dexmedetomidine given in elderly patients

HUANG Xu

First People's Hospital of Zhaoqing City in Guangdong Province，Zhaoqing 526020，China

[Abstract] Objective To observe the protective effect of dexmedetomidine in the perioperative myocardial function of elderly patients. Methods 58 cases with total hip replacement surgery in elderly patients were selected and randomly divided into two groups，29 cases in the observation group，before induction of anesthesia received dexmedetomidine given intravenously，29 cases in the control group， no additional give dexmedetomidine fixed or other drugs affect cardiac function，incidence of myocardial ischemic changes and blood rheology and serum cTnⅠ and changes GP-BB between the two groups were observed and compared. Results Myocardial ischemic electrocardiographic changes in the observation group with the incidence of 6.90% was significantly lower than that in the control group，31.03%;Serum cTnⅠ and GP-BB of the two groups in the end of surgery were increased than before anesthesia（P

[Key words] Dexmedetomidine given;Cardiac function;Elderly patients

老年人血管自身调节功能往往较差，特别是合并高血压的老年患者，由于全身小血管粥样硬化，存在明显的血管重构[1]，因此在气管插管中及术中易因机械性刺激或创伤刺激发生严

重的血压不稳定，造成脏器功能不全甚至衰竭[2]。本研究以行择期全髋置换术的58例老年患