儿童新型隐球菌性脑膜炎13例脑脊液特点及疗效分析

儿童新型隐球菌性脑膜炎13例脑脊液特点及疗效分析

周莹莹;樊彩芳;罗强

【期刊名称】《医学与哲学》

【年(卷),期】2015(000)012

【摘要】To analyze the cerebrospinal fluid(CSF) features ,treatment and outcome of cryptococcus neoformans meningitis (CNM) in children .The clinical data of 13 children with CNM admitted to pediatric department of the First Hospital Affiliated to Zhengzhou University from January 2010 to September 2014 ,were analyzed retrospectively .Cryptococcus was found in CFS in 13 children (100% ) after ink staining smear .The first CSF cytology and biochemistry :white blood cell count increased ,protein content increased ,glucose content reduced obviously .The dynamic comparison of each index in 3 weeks:the protein content increased progressively .Among the 13 children receiving amphotericin B/fluconazole and flucytosine treatment ,8 cases cured ,2 cases were improved ,and 3 cases gave up any further treatment .Therefore , making a definite diagnosis of cryptococcus neoformans meningitis depend on CSF ink staining to find cryptococcus ,if the protein content increased progressively in 3 weeks ,the CNM should be highly suspected .Timely ,combined ,long‐time and multipath antifungal treatment should be given once confirmed .%为了分析新型隐球菌性脑膜