产品名: N-Benzylacetamidine (hydrobromide)修订日期: 6/30/2016产品说明书
化学性质
产品名:
N-Benzylacetamidine (hydrobromide) Cas No.:
186545-76-6 分子量:
229.1 分子式:
C9H12N2 · HBr 化学名:
N-(phenylmethyl)-ethanimidamide, monohydrobromide SMILES:
CC(NCC1=CC=CC=C1)=N.Br 溶解性:
Soluble in DMSO 储存条件:
Store at -20°C 一般建议: For obtaining a higher solubility , please warm the tube at 37°C
and shake it in the ultrasonic bath for a while.Stock solution can be
stored below -20°C for several months.
运输条件:
Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
生物活性
靶点 :
Others 信号通路:
iNOS 产品描述:
IC50: 0.20 μM: inhibits inducible nitric oxide synthases (iNOS).
IC50: 350 μM: blocks endothelial nitric oxide synthases (eNOS).
N-Benzylacetamidine is a potent and selective inhibitor of iNOS compared to eNOS. NOS is
essential to the formation of nitric oxide (NO) via the NADPH- and O2-dependent oxidation of L-arginine, which plays a role in regulating many pathological and physiological processes,
including smooth muscle relaxation and neurotransmission. INOS contributes to immune
response and inflammation while eNOS plays a vital role in regulating vascular tone.
In vitro: N-Benzylacetamidine showed good iNOS and almost negligible eNOS inhibition in THP-1 cells, a human myelomonocytic leukemia cell line [1].
In vivo: Up to now, in vivo study of N-Benzylacetamidine is still in the development stage.
参考文献:
[1]. Maccallini, C., Patruno, A., Besker, N., Ali, J., Ammazzalorso, A., & De Filippis, B. et al. Synthesis, Biological Evaluation, and Docking Studies of N-Substituted Acetamidines as Selective Inhibitors of Inducible Nitric Oxide Synthase. Journal of Medicinal Chemistry. 2009; 52(5):
1481-1485.
特别声明
产品仅用于研究,
不针对患者销售,望谅解。
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