实验--甲硝唑药动学参数的测定

t

A C logC Cr logCr 0.25

0.68211.96621 1.07795711.2852 1.05250.5

0.7813.64632 1.1350167.86170.89551

0.7613.30344 1.1239642

0.74813.09771 1.1171953

0.58410.2861 1.0122515

0.288 5.2114720.716968

0.33 5.931520.773166a'=1.2095b'=-0.628C 0'=log -1a'=16.1994(mg/L)Ka=b'*-2.303=1.4463(h -1)

T 1/2Ka =0.693/Ka=0.4792(h)

取t=2,3,5时的logC值

a=1.4003b=-0.1354C 0=log -1a=25.14(mg/L)

Ke=-2.303*b=0.3118(h -1)

T 1/2Ke =0.693/Ke=2.2229(h)

Tmax=[ln(Ka/Ke)]/(Ka-Ke)=1.3525(h)AUC=C 0'/Ke+C 0/Ka=69.3367(h*mg*L -1)Cmax=C 0*e -Ke·Tmax -C 0'*e -Ka·Tmax =14.1993(mg/L)