坐骨神经损伤后瓦勒溃变早期：紧密连接蛋白14的作用

坐骨神经损伤后瓦勒溃变早期：紧密连接蛋白14的作用

来自中国江苏省神经再生重点实验室的姚登兵所在团队的一项研究结果证实，紧密连接蛋白14在坐骨神经损伤瓦勒溃变早期（0-4 d）促进损伤神经修复的分子机制可能与其参与调节c-jun信号通路的转导有关，而与Akt和ERK1/2通路无关。

有研究表明，周围神经损伤后瓦勒溃变过程中c-Jun、Akt和ERK1/2的表达可为神经修复与再生创造有利条件，因此早期信号途径的激活至关重要。紧密连接蛋白14是的紧密连接分子蛋白的一种，可参与不同细胞紧密连接的形成。课题组以往研究报道了在大鼠坐骨神经损伤后Wallerian溃变早期（0-4 d），紧密连接蛋白14可促进损伤神经修复与再生，但其机制是否与c-Jun、Akt和ERK1/2的表达有关仍不明确。

文章进一步阐述了紧密连接蛋白14在大鼠坐骨神经损伤后瓦勒溃变早期发挥作用的分子机制，以期为为周围神经损伤修复与功能重建等提供理论基础。文章发表在《中国神经再生研究（英文版）》杂志2014年12月第24期。

Article: " The effects of claudin 14 during early Wallerian degeneration after sciatic nerve injury," by Leilei Gong1, Yun Zhu1, Xi Xu1, Huaiqin Li1, Weimin Guo1, Qin Zhao3, Dengbing Yao1, 2 (1 Jiangsu Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong, Jiangsu Province, China; 2 School of Life Sciences, Nantong University, Nantong, Jiangsu Province, China; 3 Key Laboratory of People’s Liberation Army, Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China)

Gong LL, Zhu Y, Xu X, Li HQ, Guo WM, Zhao Q, Yao DB. The effects of claudin 14 during early Wallerian degeneration after sciatic nerve injury. Neural Regen Res. 2014;9(24):2151-2158.

Role of claudin 14 during early Wallerian degeneration after sciatic nerve injury

Dengbin Yao, Jiangsu Key Laboratory of Neuroregeneration, China and his colleagues recently reported that the molecular mechanism by which claudin 14 promotes nerve repair and regeneration in the early stages of Wallerian degeneration (0–4 days) after sciatic nerve injury is related to claudin 14 participating in the regulation of C-Jun, but not Akt and ERK1/2, signal pathway.

Early activation of C-Jun, Akt and ERK1/2 expression during early Wallerian degeneration after peripheral nerve injury is of great importance for nerve repair and regeneration. Claudin 14, a tight-junction membrane protein, participates in the maintenance of cellular polarity and paracellular transportation of molecules. Dengbin Yao et al. previously reported that caudin 14 can promote repair and regeneration of injured nerve, but whether the underlying mechanism is related to C-Jun, Akt and ERK1/2 expression is unclear.

Dengbin Yao et al. further clarified the molecular mechanism underlying the role of claudin 14 in the early stages of Wallerian degeneration after sciatic nerve injury, hoping providing theoretical evidence for peripheral nerve injury repair and functional reconstruction. The relevant study was published in Neural Regeneration Research (Vol. 9, No. 24, 2014).

Article: " The effects of claudin 14 during early Wallerian degeneration after sciatic nerve injury," by Leilei Gong1, Yun Zhu1, Xi Xu1, Huaiqin Li1, Weimin Guo1, Qin Zhao3, Dengbing Yao1, 2 (1 Jiangsu Key Laboratory of

Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong, Jiangsu Province, China; 2 School of Life Sciences, Nantong University, Nantong, Jiangsu Province, China; 3 Key Laboratory of People’s Liberation Army, Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China)

Gong LL, Zhu Y, Xu X, Li HQ, Guo WM, Zhao Q, Yao DB. The effects of claudin 14 during early Wallerian degeneration after sciatic nerve injury. Neural Regen Res. 2014;9(24):2151-2158.