Long Term Perinatal Deltamethrin Exposure Alters Electrophysiological Properties of Embryo

Long Term Perinatal Deltamethrin Exposure Alters Electrophysiological Properties of Embryonic

Ventricular Cardiomyocyte

Hong-yan LUO[1];Jacob Masika[1,2];Xiu-wen Guan[3];Li NIE[1,4];Dong-hui AO[1];Yu QI[1];Rui SHI[1];Jurgen Hescheler[5];Ying ZENG[6];

【期刊名称】《当代医学科学(英文)》

【年(卷),期】2019(039)001

【摘要】Increased use of pyrethroids and the exposure to pyrethroids for pregnant women and children have raised the concerns over the potential effect of pyrethroids on developmental cardiotoxicity and other abnormalities.The purpose of this study was to investigate whether long tenn peri natal deltamethrin exposure altered embryonic cardiac electrophysiology in mice.Pregnant mice were administered with 0 or 3 mg/kg of deltamethrin by gavage daily from gestational day(gd)10.5 to gd 17.5.Whole cell patch-clamp technique was used in electrophysiological study,and real time RT-PCR was applied to analyze the molecular changes for the electrophysiological properties.Deltamethrin exposure resulted in increased mortality of pregnant mice and decreased viability of embryos.Moreover,deltamethrin slowed the maximum depolarization velocity(Vmax),prolonged the action potential duration(APD)and depolarized the maximuin diastolic potential(MDP)of embryonic