维生素D与骨骼肌

维生素D与骨骼肌

曾琴;谢忠建

【期刊名称】《中华骨质疏松和骨矿盐疾病杂志》

【年(卷),期】2016(009)002

【摘要】维生素D是调节钙磷代谢和维持骨骼健康的重要激素前体，然而近年来大量临床研究结果显示，维生素D缺乏可出现肌力下降、跌倒风险增加，而补充维生素D能够帮助增强肌力、减少跌倒机会从而降低骨折风险。但维生素D如何作用于骨骼肌，并不十分清楚，动物和细胞实验研究发现维生素D对骨骼肌的作用可能包括直接作用和间接作用，即直接通过激活肌细胞内的维生素D受体或其他因子和间接通过调节血钙和血磷水平。如能阐明维生素D在骨骼肌细胞内的作用机制，将有助于指导维生素D的临床应用，从而预防跌倒以降低骨质疏松性骨折风险。%Vitamin D is an important hormone precursor regulating calcium and phosphate homeostasis and keeping bone healthy.However, a large number of clinical trials in recent years have shown that vitamin D deficiency decreases muscle strength and increases risk of fall and vitamin D supplementation enhances muscle strength and reduces risk of fall , and therefore reduces risk of fractures .However, the mechanism by which vitamin D works on skeletal muscle remains unclear .The research in the literature has indicated that the effect of vitamin D on skeletal muscle may be direct and /or indirect.The direct effect is probably via activation of the vitamin D receptor (VDR) or unknown factors in muscle cells , and the indirect