Lomitapide mesylate_202914-84-9_DataSheet_MedChemExpress

Product Name:

Lomitapide mesylate CAS No.:

202914-84-9Cat. No.:

HY-14668MWt:

789.83Formula:

C40H41F6N3O5S Purity :>98%

Solubility:

Mechanisms:

Biological Activity:

References:

Caution: Not fully tested. For research purposes only

Medchemexpress LLC

https://www.wendangku.net/doc/5516159307.html,

[1]. Sulsky R, et al. 5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP. Bioorg Med Chem

Lett. 2004 Oct 18;14(20):5067-70.

[2]. Lomitapide. Am J Cardiovasc Drugs. 2011 Oct 1;11(5):347-52.[3]. Perry CM. Lomitapide: a review of its use in adults with homozygous familial hypercholesterolemia. Am J

Cardiovasc Drugs. 2013 Aug;13(4):285-96.Lomitapide mesylate(AEGR-733; BMS-201038) is an inhibitor of microsomal triglyceride-transfer protein

(MTP) wtih in vitro IC50 of 8 nM.

IC50 value: 8 nM [1]

Target: MTP inhibitor Lomitapide is a small-molecule, microsomal triglyceride transfer protein (MTP) inhibitor, for the treatment of both familial and primary hypercholesterolemia. Oral, once-daily lomitapide will be targeted at patients resistant to HMG-CoA reductase inhibitors (statins) either due to abnormalities in liver function or to discontinuation because of muscle pain.

Pathways:Others; Target:Others

Product Data Sheet

11D e e r P a r kD r i v e , S u i t e 102D M o n m o u t h J u n c t i o n , N J 08852,U S A

E m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r e s s .c o m