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基于相关性分析的微阵列数据集成分类研究

于化龙等:基于相关性分析的微阵列数据集成分类研究

335

[173

[18]

Gunn

R.Support

vector

machinesforclassificationand

regression[EB/OL].(1998-05-10)[2008—11—23].httpi//users.ecs.soton.ac.uk/srg/publications/pdflSVM.pdf

Wang

H,Makedon

S,FordJC。eta1.HykGene:A

hybrid

approachfor

selectingmarkergenes

forphenotype

classification

using

microarray

genc

expression

data口].

Bioinformatics,2005,21(8):1530—1537

Yu

Hualong,bornin

1982.Receivedhis

masterdegree

in

computer

sciencefrom

Harbin

Engineering

University

in

2008.

Heiscurrently

PhDcandidateofHarbinEngineeringUniversity.Student

member

ofChina

Computer

Federation.His

current

research

interestsmainly

include

bioinformatics,patternrecognition

andmachinelearning.

于化龙,1982年生。博士研究生,中国计算机学会学生会员,主要研究方向为生物信息学、模式识别与机器学习.

GuGuochang。bornin1946.ProfessorandPhDsupervisoroftheCollegeofComputer

Science

and

Technology。

Harbin

EngineeringUniversity,Harbin,China.

Hismainresearchinterestsinelude

pattern

recognition.mxageprocessing,

machine

learning

and

bioinformaticS.

顾国昌,1946年生,教授,博士生导师,主要研究方向为模式识别、图像处理、机器学习与生物信息学.

Liu

Haibo,born

in1976.PhD

and

associate

professor.Hismain

research

interests

include

image

processing

and

pattern

recognition.

刘海波,1976年生,博士,副教授,主要研

究方向为图像处理与模式识别.

Shen

Jing,born

in1969.PhDand

associate

professor.

Her

盐in

research

interestsincludeimage

processinganddata

mining.

沈■。1969年生,博士,副教授,主要研

究方向为图像处理与数据挖掘.

zlh钟Jing?born

in1972.PhD

and

associateprofessor.Hermain

researchinterests

include

software

testing,

softwarereliabilityevaluationandmachine

learning.

赵靖,1972年生,博士,副教授,主要研究方向为软件测试、软件可靠性评估与机器学习.

ResearchBackground

This

workis

partiallysupportedby

National

NaturalScienceFoundationof

China

under

grant

No.60873036,China

PostdoctoralScienceFoundation

Funded

ProjectundergrantNo.20060400809andtheScienceandTechnology

Special

FoundationforYoungResearchersofHeilongjiangProvinceofChinaundergrantNo.QC06C022.

Microarrayis

novelbiologytechnologyanditprovidestheability

tO

measuretheexpressionlevelsofthousandsof

genes

simultaneouslyin

singleexperimentandmakesitpossible

to

providediagnosisfordisease,especiallyfortumor,atmolecular

level.However,italso

presentschallengefortraditionaldataanalysismethodsandpatternclassificationmethodsbecausethere

area

largenumber

of

gene

expressionvalues

per

experiment,and

relatively

small

number

of

experiments.Therefore,

researchershavebeenmoreinterestedinensembleclassificationalgorithmwithbetterperformance.Inthispaper,wepropose

novelensembleclassification

algorithm

of

microarray

data

based

on

correlationanalysis

to

solvethe

problems

oflow

classification

accuracy

andexcessivecomputationofthe

current

ensembleclassificationalgorithms,andapplythealgorithm

tO

LeukemiamicroarraydatasetandcolontumordatasettO

validateitsfeasibilityandeffectiveness.Thisworkisexpected

tO

help

medicineresearchersanddoctorstO

design

an

accurate,fast

andlow

storage

tumorclinical

diagnostic

systembased

on

microarraydatainthe

near

future.

基于相关性分析的微阵列数据集成分类研究

作者:于化龙, 顾国昌, 刘海波, 沈晶, 赵靖, Yu Hualong, Gu Guochang, Liu Haibo,Shen Jing, Zhao Jing

作者单位:哈尔滨工程大学计算机科学与技术学院,哈尔滨,150001

刊名:

计算机研究与发展

英文刊名:JOURNAL OF COMPUTER RESEARCH AND DEVELOPMENT

年,卷(期):2010,47(2)

被引用次数:2次

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