Modulation by anti-oketsu formulations in Kampo medicine of human arterial stiffness

Modulation by anti-oketsu formulations in Kampo medicine of human arterial stiffness

Hiroyasu Satoh

【期刊名称】《传统医学研究（英文版）》

【年(卷),期】2017(002)003

【摘要】目的:比较四种活血化瘀方对瘀血人群和非瘀血人群心血管功能的影响.方法:发射脉冲和反射脉冲形成桡动脉搏动波,其比值即反射波增强指数(AI)反映了动脉硬化的程度.根据瘀血证诊断评分标准把受试者分为瘀血组(n=76)和非瘀血组(n=37),均口服抗活血化瘀方(当归芍药散、加味逍遥散、桂枝茯苓丸或者桃核承气汤),之后连续60分钟监测AI、血压、心率和中心动脉压.结果:在服药后40-60分钟,瘀血组的AI降低6-18%,其中桃核承气汤组的AI降低18.3±3.1%(P<0.01,n=15).同时瘀血组中心动脉压也降低,其中桃核承气汤治疗组中心动脉血压降低9.1±2.0%(P<0.05,n=15),加味逍遥散组的中心动脉血压降低9.0±1.8%(P<0.05,n=23).所有处方对非瘀血组AI、血压、心率和中心动脉压没有显著影响.结论:活血化瘀方能改善瘀血人群的动脉硬化.%Objective:In traditional herbal medicine (Kampo medicine in Japan),"sho"is diagnosed by the traditional assessments of clinical conditions. Among a variety of the shos, there is an"oketsu"syndrome, which is a stagnation and disturbance of microcirculation. The prompt effects of four anti-oketsu formulations in Kampo medicine on cardiovascular functions were compared in oketsu and non-oketsu persons. Methods:The arterial pulse wave from radial artery is formed by the combination with