VcMMAE_646502-53-6_DataSheet_MedChemExpress

Product Name:

VcMMAE CAS No.:

646502-53-6Cat. No.:

HY-15575

Product Data Sheet

MWt:

1316.63Formula:

C68H105N11O15Purity :>98%

Solubility:

DMSO

y Mechanisms:Biological Activity:

VcMMAE is an antibody drug conjugate (ADC)with potent antitumor activity by using the anti mitotic Pathways:Cell Cycle/DNA Damage; Target:Microtubule/Tubulin Pathways:Antibody-drug conjugates/ADCs Related; Target:Antibody-

drug conjugates VcMMAE is an antibody-drug conjugate (ADC) with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-

citrulline (vc).

IC50 value:

Target: Antibody-drug conjugate; Tubulin Monomethyl auristatin E is an antimitotic agent which inhibits cell division by blocking the

polymerisation of tubulin.Antibody-drug conjugates (ADCs) are designed to combine the exquisite specificity of antibodies to target tumor antigens with the cytotoxic potency of chemotherapeutic drugs. In vivo studies References:

[1]. Boswell, C. Andrew; Mundo, Eduardo E.; Zhang, Crystal et al. Impact of Drug Conjugation on Pharmacokinetics and Tissue Distribution of Anti-STEAP1 Antibody-Drug Conjugates in Rats.

Bioconjugate Chemistry (2011), 22(10), 1994-2004.g g y p y p g

demonstrated that the peptide-linked conjugates induced regressions and cures of established tumor xenografts with therapeutic indices as high as 60-fold. These conjugates illustrate the

importance of linker technology, drug potency and conjugation methodology in developing safe and efficacious mAb dru

[2]. Kim, Kristine M.; McDonagh, Charlotte F.; Westendorf, Lori et al. Anti-CD30 diabody-drug

conjugates with potent antitumor activity. Molecular Cancer Therapeutics (2008), 7(8), 2486-2497.[3]. Law, Che-Leung; Cerveny, Charles G.; Gordon, Kristine A. et al. Efficient elimination of B-lineage lymphomas by anti-CD20-auristatin conjugates. Clinical Cancer Research (2004), 10(23),

7842-7851.[4]. Klussman, Kerry; Mixan, Bruce J.; Cerveny, Charles G. et al. Secondary mAb-vcMMAE

Conjugates Are Highly Sensitive Reporters of Antibody Internalization via the Lysosome Pathway.

Bioconjugate Chemistry (2004), 15(4), 765-773.[5]D Caution: Not fully tested. For research purposes only

Medchemexpress LLC

https://www.wendangku.net/doc/6416287729.html,

[5]. D...

18W i l k i n s o n W a y , P r i n c e t o n , N J 08540,U S A

E m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r

e s s .c o m