UNC0646_1320288-17-2_DataSheet_MedChemExpress

Product Name:

UNC0646CAS No.:

1320288-17-2

Product Data Sheet

Cat. No.:

HY-13807MWt:

621.90Formula:

C36H59N7O2Purity :

>98%

Solubility:Mechanisms:

Biological Activity:

Pathways:Cell Cycle/DNA Damage; Target:HMTase DMSO

g y

UNC0646 is a potent and selective G9a inhibitor with IC50 of 6 nM.

IC50 value: 6 nM [1]

Target: G9a UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases,G9a and GLP (IC50 values are 6 nM and 15 nM for G9a and GLP, respectively). UNC0646 potently blocks G9a/GLP methyltransferase activity in cells (IC50 = 10 nM in MCF7 cells); exhibits low

cellular toxicity (EC50 = 4.7 μM in MCF7 cells). UNC0646 is selective for G9a/GLP over a range of other protein lysine methyltransferases and protein arginine methyltransferases.References:

[1]. Liu F, et al. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J Med

Chem. 2011 Sep 8;54(17):6139-50.p y y p g y

Caution: Not fully tested. For research purposes only

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