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Synthesis of a hypocrellin B-polyamide conjugate as DNA-targeting photosensitizer

Synthesis of a hypocrellin B-polyamide conjugate as DNA-targeting photosensitizer

Yan Yan Liu ;Sheng Qin Xia ;Zhang Hua Zeng;Rui Qiao;Xue Song Wang ;Bao Wen Zhang

【期刊名称】《中国化学快报(英文版)》

【年(卷),期】2008(019)002

【摘要】 A new hypocrellin B (HB)derivative bearing a bispyrrolecarboxamide-containing side chain was synthesized,which presents improved absorptivity in phototherapeutic window than Hb and affinity feature towards dsDNA.

【总页数】4页(157-160)

【关键词】Hypocrellin;Polyamide;Groove binding;DNA affinity

【作者】Yan Yan Liu ;Sheng Qin Xia ;Zhang Hua Zeng;Rui Qiao;Xue Song Wang ;Bao Wen Zhang

【作者单位】Lab of Organic Optoelectronic Functional Materials and Molecular Engineering,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing 100080,PR China;Graduate School of Chinese Academy of Sciences,Beijing 100049,PR China;Lab of Organic Optoelectronic Functional Materials and Molecular Engineering,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing 100080,PR China;Lab of Organic Optoelectronic Functional Materials and Molecular