PF-3758309_898044-15-0_DataSheet_MedChemExpress

Product Name:

PF-3758309CAS No.:

898044-15-0

Product Data Sheet

Cat. No.:

HY-13007MWt:

490.62Formula:

C25H30N8OS Purity :

>98%

Solubility:Mechanisms:

Biological Activity:

Pathways:Cell Cycle/DNA Damage; Target:PAK4DMSO

g y PF-3758309 is an orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PAK4 inhibitor PF-3758309 binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival.

References:

[1]. Murray, Brion W.; Guo, Chuangxing; Piraino, Joseph. Small-molecule p21-activated kinase inhibitor PF3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proceedings of the National Academy of Sciences of the United States of America (2010), 107(20), 9446-9451,S9446/1-S9446/18.

[2]. Murray BW, Guo C, Piraino J, Westwick JK, Zhang C, Lamerdin J, Dagostino E, Knighton D, Loi CM, Zager M, Kraynov E, Popoff I, Christensen JG, Martinez R, Kephart SE, Marakovits J, Karlicek

S, Bergqvist S, Smeal T.Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic

signaling and tumor growth.

Proc Natl Acad Sci U S A. 2010 May 18;107(20):9446-51.

[3]. Zhao ZS, Manser E.

Do PAKs make good drug targets?F1000Bi l R 2010S 23270Caution: Not fully tested. For research purposes only

Medchemexpress LLC

https://www.wendangku.net/doc/7118293409.html,

F1000 Biol Rep. 2010 Sep 23;2:70.

18W i l k i n s o n W a y , P r i n c e t o n , N J 08540,U S A

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