The Effect of Fibronectin on the Fertilization Capacity of Human Spermatozoa

The Effect of Fibronectin on the Fertilization Capacity of Human Spermatozoa

许复华;崔晓;杨抚华

【期刊名称】《生殖与避孕：英文版》

【年(卷),期】1996(007)001

【摘要】Fibronectin (Fn) is a major molecular glycoprotein that is known to play an important role in many systems involved in cell-to-cell interation and cell-to-matrix adhesion. We initially studied the effect of Fn on the fertilization capacity of human spermatozoa with a penetration test in vitro. Following co-incubation of Fn in a heterologous system (human spermatozoa and zona-free golden hamster oocytes ), we have noted a significant decrease in the rate of sperm penetration into oolemma at 2.8 μg Fn/ml,and a complete inhibition of fertilization at 15 μg Fn/ml. Besides, we noted a specific increase in the penetration rate during the co incubation of anti-Fn-serum in a heterologous system. These results suggest that extrinsic Fn binds with the Fn-receptor in the oolemma, thereby, competitively inhibiting fertilization.

【总页数】7页(7-13)

【关键词】人类;生殖能力;精子质量;受精能力;免疫血清

【作者】许复华;崔晓;杨抚华

【作者单位】