恶性肿瘤并发静脉血栓的药物治疗和预防进展
西南国防医药2017年6月第27卷第6期?643 ?
导意见。由于Balo病发病率极低，因此，要进行较大规模 的临床试验需要国际间、多中心的协作收集病例，而后希 望能够形成较为明确的治疗指导意见。同时还需要进一步 进行神经病理、神经免疫学以及神经遗传学的深人研究，以进一步探明其发病机制，为后续的防治提供基础。
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(收稿日期：2016-08-28)
恶性肿瘤并发静脉血栓的药物治疗和预防进展陈玉莲，丁振宇
[关键词]恶性肿瘤;静脉血栓;药物治疗;预防;进展
中图分类号R 730.6 文献标识码A
文章编号1004-0188(2017)06-0643-03 doi:10.3969/j.issn.1004-0188.2017.06.041
静脉血栓栓塞（venous lhromboembolism，VTE)是因血液在静脉中异常凝结引起静脉回流障碍而发生的一种常见并发症，在下肢中具有较高的发生率，其引起的血栓脱 洛可能引起包括肺动脉栓塞在内的严重并发症。19世纪
作者单位院610041成都，四川大学华西医院肿瘤科
通信作者：丁振宇，电话：189********;E-mail:dingzy333@163.末首次被报道恶性肿瘤引起静脉血栓，指出血栓是因恶性 肿瘤在血液系统继发性特殊变化的结果，表现为自发性血 管内凝血[|]。VTE在恶性肿瘤患者中的发生率约为4%~ 20%，是恶性肿瘤患者最常见的严重并发症之一[2]。国外研 究发现，超过一半的恶性肿瘤患者伴有不同程度的血栓形 成[3]。目前普遍认为，V TE的发生使肿瘤患者的治疗复杂 化，并成为除肿瘤本身之外导致肿瘤患者死亡的重要因