Nav1.7-IN-2_1332295-35-8_DataSheet_MedChemExpress

Product Name:

Nav1.7-IN-2CAS No.:

1332295-35-8Product Data Sheet

Cat. No.:

HY-19366MWt:

407.44Formula:

C22H22FN5O2Purity :

>98%

Solubility:Mechanisms:

Biological Activity:

Pathways:Membrane Tranporter/Ion Channel; Target:Sodium Channel 10 mM in DMSO

g y Nav1.7-IN-2 is an inhibitor of voltage-gated sodium channels (Nav), in particular Nav 1.7, with IC50

of 80 nM.

IC50 value: 80 nM

Target: Nav 1.7Nav1.7-IN-2 is useful for the treatment of diseases treatable by inhibition of these channels, in

particular, chronic pain disorder. The more detailed information please refer to WO 2011103196 A1.Nav1.7-IN-2 is a Nav1.7 channel inhibitor extracted from patent WO/2011103196 A1, compound example J, has an IC50 of 80 nM.References:

[1]. Bregman Howard, et al. Preparation of aryl carboxamide derivatives as sodium channel

inhibitors for treatment of pain. From PCT Int. Appl. (2011), WO 2011103196 A1 20110825.p

Caution: Not fully tested. For research purposes only

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