阿托伐他汀对慢性充血性心力衰竭患者超敏C反应蛋白和B型脑钠肽的影响

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阿托伐他汀对慢性充血性心力衰竭患者超敏C反应蛋白和B型脑钠肽的影响

作者：陈燕芬丁玉琴张录平王龙平孙可可

来源：《中国实用医药》2014年第26期

【摘要】目的观察阿托伐他汀对慢性充血性心力衰竭患者脑钠肽（BNP）及超敏C-反应蛋白（hs-CRP）的影响。方法慢性充血性心力衰竭患者60例随机分为用阿托伐他汀组和常规组两组，每组30例。阿托伐他汀组在常规治疗的基础上加用阿托伐他汀10 mg/d，疗程为12周。比较两组治疗前后血清超敏CRP和BNP水平的变化情况。结果治疗12周后，两组中BNP均较治疗前有显著减低（P

【关键词】阿托伐他汀；慢性充血性心力衰竭；B型脑钠肽；超敏C反应蛋白

Influence of atorvastatin therapy for patients with chronic congestive heart failure on B-type natriuretic peptide and high-sensitivity C-reactive protein CHEN Yan-fen， DING Yu-qin， ZHANG Lu-pin， et al. Department of Cardiology，Jurong People’s Hospital， Jurong 212400， China

【Abstract】 Objective To observe the effect of atorvastatin for paients with chronic congestive heart failure （CCHF） on the changes of B-type natriuretic peptide （BNP） and high-sensitivity C-reactive protein （hs-CRP）. Methods Patients with CCHF， 60 cases in all， were randomly divided into atorvastatin group and conventional group， and each group contained 30 cases. The atorvastatin group was treated with atorvastatin 10 mg/d along with routine treatment. After 12-week treatment， the changes of BNP and hs-CRP levels were detected and compared between the two groups. Results After the treatment for 12 weeks，the levels of BNP in both groups were significantly decreased， compared with those before treatment （P

【Key words】 Atorvastatin； Chronic congestive heart failure； B-type natriuretic peptide；High-sensitivity C-reactive protein

研究发现阿托伐他汀除具有调脂作用外，还具有改善内皮功能、抑制免疫反应、抗血栓

形成和稳定斑块等其他心血管保护作用[1]。慢性充血性心力衰竭，是大多心血管疾病的最终归宿，也是主要的死亡原因，预后较差。本研究选择慢性充血性心力衰竭为研究对象，观察慢性充血性心力衰竭患者阿托伐他汀治疗前后B型脑钠肽（BNP）和超敏C反应蛋白（hs-CRP）水平的变化，探讨其治疗慢性充血性心力衰竭的效果及机制。

1 资料与方法