Product Name:
DBPR108CAS No.:
1186426-66-3Cat. No.:
HY-12528MWt:
324.39Formula:
C16H25FN4O2Purity :>98%
Solubility:Mechanisms:
Biological Activity:
References:
Caution: Not fully tested. For research purposes only
Medchemexpress LLC
https://www.wendangku.net/doc/cf6046653.html,
[1]. Yeh TK, et al. (2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.
Bioorg Med Chem Lett. 2010 Jun 15;20(12):3596-600.DBPR108 is a potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15
nM; no inhibition on DDP8 and DPP9.
IC50 value: 15 nM [1]
Target: DPP4 inhibitor DBPR108 is an IC50=15 nM DPP IV inhibitor displays a more than 3000-fold selectivity over DPP8 DPP9,FAP and DPP-II. TThe in vivo effects of DBPR108, including inhibition of plasma DPP-IV activity and
suppression of blood glucose elevation, were also demonstrated. DBPR108 is a potent, selective, long-acting
and safe DPP-IV inhibitor as a potential treatment of type 2 diabetes mellitus.
Pathways:Metabolism/Protease; Target:DPP4Product Data Sheet
DMSO
11 D e e r P a r k D r i v e , S u i t e 102D M o n m o u t h J u n c t i o n , N J 08852,U S A
E m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r e s s .c o m