A Brief Review of Computational Gene Prediction Methods

A Brief Review of Computational Gene Prediction

Methods

Zhuo Wang;Yazhu Chen;Yixue Li

【期刊名称】《基因组蛋白质组与生物信息学报（英文版）》

【年(卷),期】2004(002)004

【摘要】With the development of genome sequencing for many organisms, more and more raw sequences need to be annotated. Gene prediction by computational methods for finding the location of protein coding regions is one of the essential issues in bioinformatics. Two classes of methods are generally adopted: similarity based searches and ab initio prediction. Here, we review the development of gene prediction methods, summarize the measures for evaluating predictor quality, highlight open problems in this area, and discuss future research directions.

【总页数】6页(216-221)

【关键词】gene prediction;similarity searches;ab initio prediction;Hidden Markov Model

【作者】Zhuo Wang;Yazhu Chen;Yixue Li

【作者单位】Biomedical Instrument Institute, Shanghai Jiaotong University, Shanghai 200030, China;Shanghai Center for Bioinformation Technology, Shanghai 200035, China;Biomedical Instrument Institute, Shanghai Jiaotong University, Shanghai 200030, China;Shanghai Center