Canagliflozin_842133-18-0_DataSheet_MedChemExpress

Product Name:

Canagliflozin CAS No.:

842133-18-0Product Data Sheet

Cat. No.:

HY-10451MWt:

444.52Formula:

C24H25FO5S Purity :

>98%

Solubility:Mechanisms:

Biological Activity:

Pathways:Membrane Tranporter/Ion Channel; Target:SGLT DMSO ≥85mg/mL Water

<1.2mg/mL Ethanol ≥85mg/mL

g y Canagliflozin(JNJ 28431754; TA 7284) is a highly potent and selective SGLT2 inhibitor for hSGLT2

with IC50 of 2.2 nM, exhibits 413-fold selectivity over hSGLT1.

IC50 value: 2.2 nM

Target: SGLT2Canagliflozin(JNJ 24831754ZAE; JNJ 28431754; JNJ 28431754AAA; TA 7284) is an experimental drug being developed by Johnson & Johnson for the treatment of type 2 diabetes.Canagliflozin(JNJ 24831754ZAE; JNJ 28431754; JNJ 28431754AAA; TA 7284) is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2), which is responsible for at least 90% of the glucose reabsorption References:

[1]. Sumihiro Nomura et al. Discovery of Canagliflozin, a Novel C-Glucoside with Thiophene Ring, as Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes Mellitus

J. Med. Chem., 2010, 53 (17), pp 6355-6360[2]. Nicolle LE, Capuano G, Ways K, Usiskin K.g p p ()p g p in the kidney. Blocking this transporter causes blood glucose to be eliminated through the urine....

[]p y Effect of canagliflozin, a sodium glucose co-transporter 2 (SGLT2) inhibitor, on bacteriuria and urinary tract infection in subjects with type 2 diabetes enrolled in a 12-week, phase 2 study.

Curr Med Res Opin. 2012 Jul;28(7):1167-71.

[3]. Rosenstock J, et al. Canagliflozin DIA 2001 Study Group.Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to

metformin in subjects with type 2 diabetes.

Diabetes Care. 2012 Jun;35(6):1232-8.

[4]. Liang Y , et al. Eff t f lifl i l th h ld f l l i d b d i Caution: Not fully tested. For research purposes only

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Effect of canagliflozin on renal threshold for glucose, glycemia, and body wei...

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