Solute clearance effect of citrate anticoagulation hemodialysate for hemodialysis in patie

Solute clearance effect of citrate anticoagulation hemodialysate for hemodialysis in patients with

high risk of bleeding

Zhao Guangben;Gui Baosong;Yu Changqing;Xue Jing;Sun Hongyan

【期刊名称】《西安医科大学学报(英文版)》

【年(卷),期】2008(020)004

【摘要】Objective To study the solute clearance effect of the new concentrated anticoagulation hemodiaiysate of citrate for hemodialysis in patients with high risk of bleeding. Methods Forty-two kidney failure patients with high risk of bleeding were divided into two groups (Group A and Group B) according to their hemodialysis manners. Patients in Group A were hemodialyzed with bicarbonate hemodialysate with low-molecular-weight heparin (dalteparin) anticoognlation and those in Group B with the new citrate antieoagnlation hemodialysate prepared in our hospital without any other anticoagulant. Blood urea nitrogen (BUN) and creatinine (Cr) concentrations were measured before and after dialysis, and Kt/V and urea reduction rate (URR) were calculated. In addition, activated clotting time (ACT) and ionized calcium (iCa2+) concentration were also measured at the arterial and venous ends. Results ACT was extended and iCa2+ concentration decreased significantly at the venous end compared with those at the arterial end in Group B (P<0.01). BUN and Cr concentrations were markedly