Angiotensin 1-7_51833-78-4_DataSheet_MedChemExpress

Product Name:

Angiotensin 1-7CAS No.:

51833-78-4Cat. No.:

HY-12403MWt:

899.00Formula:

C41H62N12O11Purity :>98%

Solubility:Mechanisms:

Biological Activity:

References:

Caution: Not fully tested. For research purposes only

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[1]. Alzayadneh EM, et al. Angiotensin-(1-7) abolishes AGE-induced cellular hypertrophy and myofibroblast

transformation via inhibition of ERK1/2. Cell Signal. 2014 Sep 19. pii: S0898-6568(14)00314-3.[2]. Liang B, et al. Angiotensin-(1-7) upregulates expression of ABCA1 and ABCG1 through the Mas receptor via the liver X receptor alpha signaling pathway in THP-1 macrophages treated with Angiotensin II. Clin Exp

Pharmacol Physiol. 2014 Sep 15.[3]. Cisternas F, et al. Angiotensin 1-7 Decreases Skeletal Muscle Atrophy induced by Angiotensin II through

Mas Receptor Dependent Mechanism. Clin Sci (Lond). 2014 Sep 15.[4]. Shil PK, et al. Oral Delivery of ACE2/Ang-(1-7) Bioencapsulated in Plant Cells Protects against

Experimental Uveitis and Autoimmune Uveoretinitis. Mol Ther. 2014 Sep 17.[5]. Yousif MH, et al. Chronic Treatment with Ang-(1-7) Reverses Abnorm...

Angiotensin (1-7) is a endogenous peptide fragment which can induces vasorelaxation through release of NO

and prostaglandins, perhaps through activation of a non-AT1, non-AT2 receptor, Mas.

IC50 value:

Target: in vitro: Treatment with Ang-(1-7) reversed MGA-induced cellular hypertrophy and myofibroblast transition evidenced by reduced immunostaining and protein expression of α-smooth muscle actin (α-SMA) [0.4±0.1 vs.1.0±0.1, respectively, n=3, p<0.05]. Ang-(1-7) abolished AGE-induced activation of the MAP kinase ERK1/2to a similar extent as the TGF-β receptor kinase inhibitor SB58059; however, Ang-(1-7) did not attenuate the MGA-stimulated release of TGF-β [1]. Ang-(1-7) increased ABCA1 and ABCG1 expression in a

concentration-dependent manner at both the mRNA and protein levels, promoted cholesterol efflux, and decreased cholesterol content in THP-1 macrophages tre...

Pathways:GPCR/G protein; Target:Angiotensin Receptor Product Data Sheet

DMSO

11 D e e r P a r k D r i v e , S u i t e 102D M o n m o u t h J u n c t i o n , N J 08852,U S A

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