鲑降钙素、阿法骨化醇、碳酸钙联合应用治疗骨质疏松性股骨粗隆间骨折40例疗效分析

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鲑降钙素、阿法骨化醇、碳酸钙联合应用治疗骨质疏松性股骨粗隆间骨折40例疗效分析

作者：王思成刘祥飞吴献民何金国张友忠杨国庆

来源：《上海医药》2013年第09期

摘要目的：比较鲑降钙素、阿法骨化醇、碳酸钙联合应用与单用鲑降钙素治疗骨质疏松性股骨粗隆间骨折的临床疗效。方法：将80例行闭合复位PFNA内固定术治疗的骨质疏松性股骨粗隆间骨折患者，随机分为实验组及对照组。分别给予肌注鲑降钙素+口服阿法骨化醇和碳酸钙和单纯肌注鲑降钙素。治疗6个月及1年后测定骨密度值及观察骨折愈合时间并进行比较。结果：实验组治疗6个月和1年后腰椎和股骨颈，Ward三角及大转子4个部位BMD较对照组均显著上升（P

关键词骨质疏松股骨粗隆间骨折阿法骨化醇随机对照研究

中图分类号：R977； R969.4 文献标识码：B 文章编号：1006-1533（2013）09-0024-04

Evaluation of therapeutic effect of salmon calcitonin， alfacalcidol， calcium

carbonate in the treatment of 40 cases of osteoporotic intertrochanteric fractures

WANG Sicheng， LIU Xiangfei， WU Xianmin， HE Jinguo， ZHANG Youzhong， YAN Guoqing

（Department of Orthopaedic Surgery， Shanghai Zhongye Hospital， Shanghai 200160，China）

ABSTRACT Objective： To study the clinical efficacy of a monotherapy of salmon calcitonin or a combination therapy of salmon calcitonin with alfacalcidol and calcium carbonate on osteoporotic intertrochanteric fracture. Methods： Eighty patients with osteoporotic intertrochanteric fractures who received a reduction and internal fixation with PFNA were randomly divided into either experimental group or control one. Patients in experimental group were administrated with intramuscular salmon calcitonin plus oral alfacalcidol and calcium carbonate while only intramuscular salmon calcitonin was given in control group. BMD was measured again after 6 months or 1 year treatment， and fracture healing time was observed. The obtained data were statistically analyzed. Results： BMD of lumbar spine， neck of femur，trochiter and Ward’s triangular area were more significantly increased in experimental group than in control group （P