AZD-9291 dimesylate__DataSheet_MedChemExpress

Product Name:

AZD-9291 dimesylate CAS No.:

Cat. No.:

HY-79077MWt:

691.82Formula:

C30H41N7O8S2Purity :>98%

Solubility:Mechanisms:Biological Activity:

References:

Caution: Not fully tested. For research purposes only

Medchemexpress LLC

https://www.wendangku.net/doc/ea9673804.html,

[1]. Patent WO 2013014448 A1: 2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as egfr modulators

useful for treating cancer

.AZD-9291 dimesylate is a potent and selective mutated forms EGFR inhibitor(Exon 19 deletion EGFR

IC50=12.92 nM, L858R/T790M EGFR IC50= 11.44 nM, wild type EGFR IC50= 493.8 nM).

IC50 value: 12.92 nM(Exon 19 deletion EGFR); 11.44 nM(L858R/T790M EGFR) [1]

Target: L858R/T790M EGFR; Exon 19 deletion EGFR AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. It inhibits both activating and

resistant EGFR mutations while sparing the normal form of EGFR that is present in normal skin and gut cells,

thereby reducing the side effects encountered with currently available medicines.

Patent: WO 2013014448...

Pathways:JAK/STAT Signaling; Target:EGFR

Pathways:Protein Tyrosine Kinase/RTK; Target:EGFR Product Data Sheet

DMSO

11 D e e r P a r k D r i v e , S u i t e 102D M o n m o u t h J u n c t i o n , N J 08852,U S A

E m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r e s s .c o m