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Taltobulin trifluoroacetate_228266-41-9_DataSheet_MedChemExpress

Product Name:

Taltobulin trifluoroacetate CAS No.:

228266-41-9Cat. No.:

HY-15584A MWt:

587.67Formula:

C29H44F3N3O6Purity :>98%

Solubility:

Mechanisms:Biological Activity:

References:

Caution: Not fully tested. For research purposes only

Medchemexpress LLC

http://www.wendangku.net/doc/eb25b2a7f5335a8102d220ce.html

[1]. Vashist YK, et al. Inhibition of hepatic tumor cell proliferation in vitro and tumor growth in vivo by taltobulin, a synthetic analogue of the tripeptide hemiasterlin. World J Gastroenterol. 2006 Nov

14;12(42):6771-8.[2]. Hadaschik BA, et al. Targeting prostate cancer with HTI-286, a synthetic analog of the marine sponge

product hemiasterlin. Int J Cancer. 2008 May 15;122(10):2368-76.Taltobulin trifluoroacetate (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs

cytotoxin.

IC50 value:

Target: tubulin in vitro: HTI-286 significantly inhibited proliferation of all three hepatic tumor cell lines (mean IC50 = 2 nmol/L +/- 1 nmol/L) in vitro. Interestingly, no decrease in viable primary human hepatocytes (PHH) was detected under HTI-286 exposure [1]. In all cell lines tested, HTI-286 was a potent inhibitor of proliferation and induced marked increases in apoptosis. Despite similar transcriptomic changes regarding cell death and cell cycle regulating genes after exposure to HTI-286 or docetaxel, array analysis revealed distinct molecular

signatures for both compounds [2].in vivo: Intravenous administration of HTI-286 significantly inhibited tumor growth in vivo (rat allograft model)

[1]. HTI-286 significantly inhibited gr...

Pathways:Antibody-drug conjugates/ADCs Related; Target:ADCs cytotoxin

Pathways:Cell Cycle/DNA Damage; Target:Microtubule/Tubulin

Taltobulin trifluoroacetate_228266-41-9_DataSheet_MedChemExpress

Taltobulin trifluoroacetate_228266-41-9_DataSheet_MedChemExpress

Product Data Sheet

11 D e e r P a r k D r i v e , S u i t e 102D M o n m o u t h J u n c t i o n , N J 08852,U S A

E m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r e s s .c o m

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