Betaxolol_63659-18-7_DataSheet_MedChemExpress
Product Name:
Betaxolol CAS No.:
63659-18-7Cat. No.:
HY-B0381Product Data Sheet
MWt:
307.43Formula:
C18H29NO3Purity :>98%
Solubility:
DMSO 62 mg/mL; Water 62 mg/mL
Mechanisms:
Biological Activity:
Betaxolol is a selective beta1adrenergic receptor blocker used in the treatment of hypertension and
Pathways:GPCR/G protein; Target:Adrenergic Receptor Betaxolol is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and
glaucoma.
Target: Beta1 Adrenergic Receptor Betaxolol is a cardioselective beta-adrenergic receptor blocking agent. Betaxolol (5 mg/kg via i.p.injection) was administered at 24 and then 44 h following the final chronic cocaine administration.Animals treated with betaxolol during cocaine withdrawal exhibited a significant attenuation of
anxiety-like behavior characterized by increased time spent in the open arms and increased entries into the open arms compared to animals treated with only saline during cocaine withdrawal.
Betaxolol did not produce anxiolytic-like effects in control animals treated chronically with saline [1].References:
[1]. Rudoy, C.A. and E.J. Van Bockstaele, Betaxolol, a selective beta(1)-adrenergic receptor antagonist, diminishes anxiety-like behavior during early withdrawal from chronic cocaine
administration in rats Prog Neuropsychopharmacol Biol Psychiatry 200731(5):p 1119-29Betaxolol produces less systemic beta 2- and possibly beta 1-adrenergic receptor blockade than either timolol or levobunolol. Betaxolol may be r...
administration in rats. Prog Neuropsychopharmacol Biol Psychiatry, 2007. 31(5): p. 111929.
[2]. Lesar, T.S., Comparison of ophthalmic beta-blocking agents. Clin Pharm, 1987. 6(6): p. 451-63.Caution: Not fully tested. For research purposes only
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